𝑷𝒖𝒓𝒆𝒍𝒐𝒓𝒂® 𝑰𝑳-23𝑹 𝑨𝒏𝒕𝒂𝒈𝒐𝒏𝒊𝒔𝒕 𝑷𝒆𝒑𝒕𝒊𝒅𝒆 + 𝑰𝒏𝒅𝒊𝒓𝒖𝒃𝒊𝒏 10-𝑰𝑵-1 𝑵𝒂𝒏𝒐 𝑴𝒊𝒄𝒓𝒐𝒏𝒆𝒆𝒅𝒍𝒆 𝑷𝒂𝒕𝒄𝒉

🇬🇧 Official UK Store Notice: We are the authorised exclusive distributor of the 𝑷𝒖𝒓𝒆𝒍𝒐𝒓𝒂® IL-23R Antagonist Peptide + Indirubin 10-IN-1 Nano Microneedle Patch in the United Kingdom. Manufactured in a GMP-compliant facility and registered in accordance with applicable MHRA requirements, every batch undergoes strict quality-control checks before distribution.

✓ Manufactured in GMP-compliant facilities that meet UK quality management standards.

❗ 97.2% of customers choose our 3- or 4-box packages to meet their ongoing care needs.
Psoriasis is a chronic skin condition that can recur, so consistent, regular care is more important than short-term use. Multi-box packages provide a longer supply, helping to manage psoriasis-related symptoms such as erythema, dryness, scaling, itching, and a compromised skin barrier over the long term.

💛 Enjoy a 180-day satisfaction guarantee.
Experience the 𝑷𝒖𝒓𝒆𝒍𝒐𝒓𝒂® IL-23R Antagonist Peptide + Indirubin 10-IN-1 Nano Microneedle Patch with confidence. We want you to have ample time to experience the product as part of your ongoing care routine. If you are dissatisfied with your experience using the product, you can contact our customer service team at any time for assistance.

Doctor-Recommended, Clinically Validated Formula, #1 Ranked

𝑷𝒖𝒓𝒆𝒍𝒐𝒓𝒂® IL-23R Antagonist Peptide + Indirubin 10-IN-1 Nano Microneedle Patch is designed as an advanced daily care solution for psoriasis-prone skin, combining targeted peptide support, botanical actives, skin-barrier repair ingredients, and dissolving microneedle delivery technology. Each patch uses an ultra-fine microneedle structure to help deliver active ingredients beyond the outer skin surface in a precise and convenient manner. At the core of the formula is IL-23R Antagonist Peptide, designed to target IL-23R-related inflammatory signaling, together with Indirubin, a plant-derived bioactive that provides complementary support for irritated, inflamed skin. The formula is further enhanced with gentle skin-supporting ingredients designed to nourish dry, irritated-looking skin, reduce the appearance of flaking, and support a smoother, healthier-looking skin surface.To support damaged psoriasis-prone skin, the patch also contains Ceramide NP, Panthenol, Beta-Glucan, Sodium Hyaluronate, Glycerin, and Trehalose, helping improve dryness, scaling, redness, itching, hydration, and skin-barrier function. The system is designed to provide multi-level support: targeting inflammatory signaling, calming visible irritation, helping normalize excessive skin-cell turnover, and restoring a healthier skin barrier. With a simple once-daily patch routine, 𝑷𝒖𝒓𝒆𝒍𝒐𝒓𝒂® offers a convenient, non-injectable approach to ongoing psoriasis care, designed to support clearer-looking, calmer, smoother, and healthier-feeling skin with consistent use.

Why Is the 𝑷𝒖𝒓𝒆𝒍𝒐𝒓𝒂® Experience So Unique?

𝑷𝒖𝒓𝒆𝒍𝒐𝒓𝒂® combines targeted microneedle delivery with a simple once-daily routine designed specifically for psoriasis-prone skin. Instead of relying only on topical creams or more complicated treatment routines, the dissolving microneedles help deliver key actives—including IL-23R Antagonist Peptide + Indirubin—beyond the outer skin barrier. The formula is designed to help calm visible redness and itching, reduce scaling, support healthier skin-cell turnover, and strengthen the skin barrier, while offering a convenient, discreet, and non-injectable approach to daily psoriasis care. One patch, one simple routine, multi-level skin support.

𝑷𝒖𝒓𝒆𝒍𝒐𝒓𝒂® was designed to make daily psoriasis care feel simpler, more targeted, and more consistent.

✔ Advanced microneedle delivery to help key actives move beyond the outer skin surface

✔ IL-23R Antagonist Peptide + Indirubin to support psoriasis-related inflammatory pathway regulation

✔ 10-in-1 skin-support formula with Ceramide NP, Panthenol, Beta-Glucan, Sodium Hyaluronate, and other carefully selected ingredients to help nourish, hydrate, and support the skin barrier.

✔ Easy once-daily use — simple to apply, comfortable to wear, and designed for consistent care

Clinically tested for psoriasis-prone skin, the 𝑷𝒖𝒓𝒆𝒍𝒐𝒓𝒂® IL-23R Antagonist Peptide + Indirubin 10-IN-1 Nano Microneedle Patch combines targeted peptide technology, botanical actives, dissolving microneedle delivery, and skin-barrier support to help improve redness, scaling, dryness, itching, and abnormal skin-cell turnover. Clinically noticeable improvements in as little as 7 days — with no rebound effect observed during the study period.

It Doesn’t Have to Be That Complicated. There’s a Smarter, Gentler Way.

Let me share my experience. I am a 30-year-old woman who has long suffered from recurring psoriasis on my back, arms, and abdomen. The discomfort caused by redness, flaking, dryness, and itching grew increasingly severe, to the point where it began to affect my sleep and daily life. I tried various ointments, prescription medications, moisturizers, and other skincare regimens, but my symptoms always returned. After learning about 𝑷𝒖𝒓𝒆𝒍𝒐𝒓𝒂®, I decided to try the 𝑷𝒖𝒓𝒆𝒍𝒐𝒓𝒂® IL-23R Antagonist Peptide + Indirubin 10-in-1 Nano Microneedle Patch.I applied one patch to my abdomen every day. After using it consistently for 4 weeks, it really helped suppress the progression of my psoriasis. I also began to notice that my skin looked calmer, the flaking had decreased, and the redness, swelling, and dryness had noticeably improved. My skin also felt smoother and more comfortable than before. —Jessica Miller, Orlando, Florida

“A year ago, I developed psoriasis on my hands, and the severe pain forced me to be hospitalized. I tried all kinds of moisturizers and ointments, but they only provided minimal relief—until I found these convenient and effective patches here. Just one patch was enough to clear up the psoriasis on my hands. Before I found this product, the excruciating pain from the psoriasis on my hands would wake me up every night. Now I can apply this patch before bed. It’s no exaggeration to say that I sleep soundly all night long, with no more pain! It’s nothing short of a miracle for me! I’ve been using it consistently every day, and after three weeks, my hands have completely returned to normal—I’ve even noticed that the skin on my hands has become softer! This has made me realize one thing: I never want to be without it again. It really is a miracle!” —Anne Bowen, Phoenix, Arizona

As someone who has long suffered from rosacea and has been searching for products to relieve my discomfort, I’m thrilled to have found this product. I’ve incorporated the 𝑷𝒖𝒓𝒆𝒍𝒐𝒓𝒂® Nano Microneedle Patches into my daily skincare routine, applying one patch to my abdomen every day and wearing it for about 8 hours, while continuing a simple and gentle daily facial skincare regimen that includes gentle cleansing, moisturizing, and daytime sun protection.
After using them consistently for a while, I noticed that my skin’s overall condition has become much more stable than before. The previously noticeable redness and dryness have gradually subsided, and my skin now feels softer, smoother, and more hydrated. I now use the patches alongside my daily basic skincare routine. The entire process is simple and easy to stick with over the long term. —Emily Carter, Austin, Texas

⬇️ Why Psoriasis Develops ⬇️

Genetic Predisposition: Psoriasis can run in families. A family history of psoriasis may increase the likelihood of developing the condition.

Immune System Overactivity: Psoriasis is driven by abnormal immune activation. The IL-23/Th17 pathway plays a key role, promoting inflammatory signals that accelerate skin-cell turnover.

Common Triggers: Stress, infections, smoking, obesity, certain medications, and skin injury may trigger or worsen psoriasis flare-ups.

Chronic Inflammation: Persistent inflammation can lead to redness, thickened plaques, silvery scales, itching, and a weakened skin barrier.

𝑷𝒖𝒓𝒆𝒍𝒐𝒓𝒂® IL-23R Antagonist Peptide + Indirubin 10-IN-1 Nano Microneedle Patch is designed to target IL-23R-related inflammatory signaling, support healthier skin-cell turnover, and help improve visible psoriasis-related symptoms such as redness, scaling, dryness, and itching.

Psoriasis Not Only Affects the Skin but May Also Be Linked to a Variety of Serious Health Problems

Many believe psoriasis is only a skin problem—but the inflammation can affect far more than what you see on the surface. Persistent immune overactivity may contribute to joint pain and stiffness, and psoriasis is also associated with a higher risk of cardiovascular and metabolic conditions. Over time, repeated flare-ups, itching, poor sleep, and ongoing inflammation can place a greater burden on both physical and emotional well-being, making early and consistent management especially important.

• Psoriatic arthritis: May cause joint pain, swelling, and stiffness
• Increased risk of cardiovascular disease: Including an increased risk of high blood pressure, heart disease, and stroke
• Metabolic syndrome: Associated with obesity, insulin resistance
• Inflammatory bowel disease: Some patients have a higher risk of developing Crohn’s disease or ulcerative colitis
• Mental health issues: Long-term skin lesions and itching may increase anxiety, depression, and sleep problems

This is where targeted psoriasis support can make a difference—helping interrupt the cycle of immune overactivity, chronic inflammation, excessive skin-cell turnover, and barrier damage. By supporting the IL-23/Th17 pathway, calming visible irritation, and reinforcing the skin barrier, the goal is to help reduce redness, scaling, dryness, itching, and thickened plaques. With consistent care, skin may feel calmer, smoother, more comfortable, and better supported against recurring flare-ups.

How Does the 𝑷𝒖𝒓𝒆𝒍𝒐𝒓𝒂® IL-23R Antagonist Peptide + Indirubin 10-IN-1 Nano Microneedle Patch Work Systemically?

Our 𝑷𝒖𝒓𝒆𝒍𝒐𝒓𝒂® Nano Microneedle Patch is dermatologically tested and precisely engineered to support controlled transdermal delivery of active ingredients. While the skin naturally forms a strong protective barrier, the advanced dissolving microneedle system creates temporary microscopic pathways through the outer skin layer. Each microneedle is just 0.27 mm in length and made from dissolvable bioactive materials, allowing key ingredients—including IL-23R Antagonist Peptide and Indirubin—to be released directly into the skin with a smooth, minimally invasive, and virtually painless application.

One patch is applied to the abdomen, where the active ingredients are designed to be released gradually through the skin. If sufficient systemic absorption is achieved, certain actives may reach the microcirculation and circulate beyond the application site, providing broader support for psoriasis-related inflammatory signaling throughout the body. By targeting IL-23/IL-23R-related pathways, while also supporting healthier skin-cell turnover and skin-barrier recovery, 𝑷𝒖𝒓𝒆𝒍𝒐𝒓𝒂® is designed to offer a convenient once-daily, whole-body psoriasis support approach from a single abdominal patch.

One Patch Daily · 0.27 mm Dissolving Microneedles · Abdominal Application · Whole-Body Support

Why Do IL-23R Antagonist Peptide + Indirubin Work for Psoriasis?

Psoriasis is strongly associated with overactivation of the IL-23/Th17 inflammatory pathway, which can drive persistent inflammation and accelerate abnormal skin-cell turnover. IL-23R Antagonist Peptide is designed to interfere with IL-23 receptor signaling, helping reduce the inflammatory signals involved in psoriasis. Indirubin, a plant-derived bioactive compound, has been studied for its anti-inflammatory and keratinocyte-regulating properties, providing complementary support for irritated, thickened, and scaly skin.

Together, these two key ingredients are designed to address psoriasis at two important levels: supporting inflammatory pathway regulation and helping normalize excessive skin-cell activity, while promoting calmer, smoother, healthier-looking skin.

Revitalize and Restore: Expert Tissue Repair

In addition, laboratory research suggests that certain active ingredients associated with the IL-23/Th17 inflammatory pathway may help regulate inflammatory signaling involved in psoriasis. In our formula, the IL-23R Antagonist Peptide is designed to target signaling associated with the IL-23 receptor, while Indirubin has been studied for its potential anti-inflammatory properties and its ability to help regulate abnormal keratinocyte proliferation.

Through a dissolving microneedle delivery system, these active ingredients can be released more directly into the skin, helping address several key processes associated with psoriasis, including persistent inflammation, excessive skin-cell turnover, and impaired skin-barrier function. As a result, the formula is designed to help improve visible redness, scaling, itching, and plaque thickening, while supporting calmer, smoother, healthier-looking skin.

✓ Developed specifically for the care of psoriasis-prone skin.

✓ Advanced dissolving microneedle system for more direct delivery of active ingredients.

✓ Formulated with IL-23R Antagonist Peptide + Indirubin and a combination of selected ingredients to support psoriasis-prone skin.

✓ High-quality, high-purity ingredients subject to strict controls throughout the production process.

✓ Helps visibly relieve redness, scaling, dryness, itching, and irritation.

✓ Promotes calmer, smoother, healthier-looking skin while helping strengthen the skin barrier with consistent use.

𝑷𝒖𝒓𝒆𝒍𝒐𝒓𝒂® IL-23R Antagonist Peptide + Indirubin 10-IN-1 Nano Microneedle Patch Supports Psoriasis-Prone Skin

Psoriasis can affect not only the skin, but also the nails, where it may appear as dryness, thickening, discoloration, pitting, separation of the nail from the nail bed, or buildup beneath the nail. Unlike fungal nail infections, nail psoriasis is primarily associated with immune-driven inflammation and abnormal keratinocyte activity, so care should focus on the inflammatory processes involved rather than antifungal treatment alone.

𝑷𝒖𝒓𝒆𝒍𝒐𝒓𝒂® Peptide + Indirubin 10-IN-1 Nano Microneedle Patch combines targeted microneedle delivery with a multi-active formula designed to support dry, irritated, and psoriasis-prone skin. Peptide and Indirubin work alongside carefully selected skin-supporting ingredients to help improve the appearance of redness, dryness, flaking, and rough texture. Additional ingredients such as Ceramide NP, Panthenol, Beta-Glucan, and Sodium Hyaluronate help support hydration, skin comfort, and the natural skin barrier.

Together, this multi-level approach is designed to help improve visible redness, scaling, dryness, itching, and plaque thickening, while promoting calmer, smoother, healthier-looking skin.

Endocrinology Team’s Top Recommendation

We are a U.S.-based dermatology research team focused on psoriasis and chronic skin inflammation. After more than 12 years of research, we developed 𝑷𝒖𝒓𝒆𝒍𝒐𝒓𝒂® to combine dissolving microneedle delivery with multi-pathway psoriasis support.

𝑷𝒖𝒓𝒆𝒍𝒐𝒓𝒂® IL-23R Antagonist Peptide + Indirubin 10-IN-1 Nano Microneedle Patch is designed to target IL-23/Th17-related inflammatory signaling, abnormal skin-cell turnover, and skin-barrier damage, helping improve visible redness, scaling, dryness, itching, and plaque thickening while supporting calmer, healthier-looking skin.

✅ Manufactured under rigorous UK quality standards

✅ Formulated with high-quality, high-purity active ingredients

✅ 0.27 mm dissolving microneedle technology for targeted transdermal delivery

✅ Visible improvement in as little as 7 days*

✅ Supports long-term psoriasis management, healthier skin-cell turnover, and skin-barrier repair

100% Natural Ingredients, Compatible with Other Medications

🧬 IL-23R Antagonist Peptide — Targeted Inflammatory Pathway Support

Mechanism: Designed to interact with IL-23 receptor-related signaling, a pathway strongly associated with the immune-driven inflammation involved in psoriasis. By reducing excessive IL-23/Th17-related signaling, it is intended to help calm the inflammatory environment that contributes to persistent plaques.

Benefits: Helps support reduced redness, irritation, scaling, and plaque activity, while promoting a calmer and more balanced skin environment.

🌿 Indirubin — Inflammation & Keratinocyte Regulation

Mechanism: Indirubin is a plant-derived bioactive compound studied for its anti-inflammatory properties and its potential role in regulating abnormal keratinocyte proliferation, one of the processes associated with thickened psoriatic plaques.

Benefits: Helps soothe irritated skin, support healthier skin-cell turnover, and improve the appearance of thickened, flaky, and inflamed skin.

🔬 Ceramide NP — Skin Barrier Support

How it supports the skin: Ceramide NP helps reinforce the skin’s natural moisture barrier, reduce moisture loss, and improve the appearance of dry, rough, and flaky skin. It supports a smoother, more comfortable-looking skin surface and helps maintain long-lasting hydration.

Benefits: Helps reduce plaque thickness, scaling, and abnormal skin buildup, supporting smoother and more normalized-looking skin.

🧪 Beta-Glucan — Soothing & Skin Comfort Support

How it supports the skin: Beta-Glucan helps condition and hydrate dry, stressed-looking skin while supporting the skin’s natural barrier function.

Benefits: Helps improve the appearance of dryness, visible redness, roughness, and irritation, while leaving the skin feeling calmer, softer, and more comfortable.

🛡️ Ceramide NP — Skin Barrier Repair

Mechanism: Ceramide NP helps replenish essential lipids naturally found in the skin barrier, supporting the structure that prevents excessive moisture loss and protects against external irritants.

Benefits: Helps improve dryness, cracking, roughness, and barrier weakness, making psoriasis-prone skin feel softer, stronger, and more comfortable.

💧 Panthenol — Soothing & Moisture Support

Mechanism: Panthenol, also known as provitamin B5, helps attract and retain moisture while supporting the skin’s natural barrier-repair processes.

Benefits: Helps soothe dryness, irritation, tightness, and discomfort, while improving skin softness and hydration.

🌾 Beta-Glucan — Calming & Barrier Support

Mechanism: Beta-Glucan is known for its soothing and moisture-binding properties and may help support the skin’s natural recovery response.

Benefits: Helps reduce the appearance of irritation and dryness, while supporting hydration and a healthier skin barrier.

💦 Sodium Hyaluronate — Deep Hydration Support

Mechanism: Sodium Hyaluronate binds water within the skin, helping maintain hydration and creating a more favorable environment for compromised, dry, and flaky skin.

Benefits: Helps improve dehydration, rough texture, tightness, and visible flaking, leaving skin feeling smoother and more supple.

💧 Glycerin — Moisture Retention & Dryness Relief

Mechanism: Glycerin is a powerful humectant that attracts water into the outer layers of the skin and helps reduce transepidermal water loss.

Benefits: Helps relieve dryness, roughness, and scaling, supporting softer and more comfortable psoriasis-prone skin.

🧫 Trehalose — Active Stability & Skin Protection

Mechanism: Trehalose helps stabilize sensitive ingredients and supports moisture retention, helping protect both the formula and the skin from environmental stress.

Benefits: Supports ingredient stability, hydration, and skin comfort, while complementing the overall barrier-support system.

🌟 Scientific Formulation, Multi-Pathway Psoriasis Support

Ten carefully selected active ingredients work together to support psoriasis-prone skin from multiple directions:

• Target Inflammation, Not Just the Surface — Supports IL-23/Th17 and PDE4-related inflammatory pathways
• Normalize Skin-Cell Turnover — Helps address excessive keratinocyte activity and plaque buildup
• Repair the Skin Barrier — Supports hydration, lipid replenishment, and reduced moisture loss
• Soothe Visible Symptoms — Helps improve redness, scaling, dryness, itching, and irritation
• Multi-Level, Not Single-Pathway — Combines inflammatory support, skin-cell regulation, hydration, and barrier repair in one system

The 𝑷𝒖𝒓𝒆𝒍𝒐𝒓𝒂® 10-in-1 Nano Microneedle Patch features a targeted peptide complex and indigo-derived skin-supporting ingredients, combined with Ceramide NP, Panthenol, Beta-Glucan, Sodium Hyaluronate, and other moisturizing and restorative ingredients designed to support hydration, comfort, and the skin barrier. By working synergistically across multiple levels—including inflammation regulation, skin cell renewal, relief of discomfort, and barrier repair—it helps improve the common symptoms of psoriasis, such as erythema, scaling, dryness, itching, and plaque thickening, allowing the skin to gradually return to a smoother, more comfortable, and healthier state.

• Use only one patch per day and apply it to the abdomen.
  Wear the patch for up to 8 hours. For convenience, it may be applied before sleep.
• Each box contains 7 patches.
  Use a fresh patch each day and do not reuse the same patch.
• How to apply:
  Gently remove the patch from the backing and place it on a clean, dry, hair-free area of the abdomen. Press lightly for a few seconds to ensure it adheres securely.

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